Lindsey Van Haute

Development of the Mitochondrial Base Editor Analysis Package (MitoBEAP).

The paper introduces MitoBEAP, an R package for analysing next-generation sequencing data from mitochondrial base-edited samples to assess off-target effects.

Mitochondrial adenine base editing of mouse somatic tissues via adeno-associated viral delivery

This study tests mitochondrial adenine base editing in mouse tissues via AAV delivery, finding low and modestly increasing editing efficiency over time.

A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit

This study identifies a late-stage quality control step in human mitochondrial ribosome large subunit assembly, showing that MRM2 ablation impairs oxidative phosphorylation through defective translation and accumulation of assembly intermediates.

YbeY is required for ribosome small subunit assembly and tRNA processing in human mitochondria

This study identifies YbeY as essential for mitochondrial ribosome small subunit assembly and tRNA processing, showing its dual role in coupling these processes.