Pedro Rebelo‐Guiomar

This study identifies SET-24, a catalytically inactive SET domain protein in C. elegans, as essential for maintaining transgenerational epigenetic memory through its interaction with HCF-1 and regulation of H3K4me3 levels.

This study shows that Clu/Clu1 proteins form mitochondrial-associated granules and regulate mitochondrial protein translation by interacting with ribosomes and mRNAs during metabolic transitions.

The paper identifies recurrent capture of transposable element domains by F-box genes across eukaryotes and shows their functional integration into host regulatory networks.

This study identifies a late-stage quality control step in human mitochondrial ribosome large subunit assembly, showing that MRM2 ablation impairs oxidative phosphorylation through defective translation and accumulation of assembly intermediates.

This study identifies YbeY as essential for mitochondrial ribosome small subunit assembly and tRNA processing, showing its dual role in coupling these processes.

This study identifies novel ELAC2 variants linked to hypertrophic cardiomyopathy and mitochondrial dysfunction, confirms their pathogenicity through in vitro analysis, and links one variant to prostate cancer.