Adam M. Dinan

This study determines the structure of CdrA, a fibrillar adhesin in Pseudomonas aeruginosa, revealing its role in biofilm formation and identifying targets for inhibition.

Trained on over 1.3 million bacterial genomes represented as ordered protein sequences, the transformer foundation model Bacformer predicts protein interactions, operons, essentiality, and phenotypes while generating trait-conditioned synthetic proteomes.

This study introduces GeneBac, a deep learning model that predicts antibiotic resistance from bacterial genomic sequences, showing accurate MIC prediction and variant effect assessment.

This study identifies a late-stage quality control step in human mitochondrial ribosome large subunit assembly, showing that MRM2 ablation impairs oxidative phosphorylation through defective translation and accumulation of assembly intermediates.

The paper identifies long reverse-frame ORFs in narnaviruses, showing coding capacity on the negative strand of positive-sense RNA viruses.

This study shows segmented negative-strand RNA viruses use upstream translation initiation to expand their coding capacity through non-AUG initiation and host mRNA leader sequence appropriation.

This study compares gene expression in virulent and attenuated IBV strains using RNASeq and RiboSeq, revealing differences in transcription, translation, and host response.