Schraga Schwartz

RTTN moonlights beyond the centrosome to control ribosome biogenesis and tRNA modification in human brain organoids

This study identifies RTTN's role in ribosome biogenesis and tRNA modification in human brain organoids, showing mutations disrupt translation and cause cortical malformations.

A variant rRNA serves as a translational repressor in Plasmodium falciparum

The paper identifies a variant rRNA in Plasmodium falciparum that represses translation during host-to-vector transmission by forming a dominant-negative ribosome.

Single-Nucleotide m6A Mapping Uncovers Redundant YTHDF Function in Planarian Progenitor Fate Selection

The paper maps single-nucleotide m6A modifications in planarians and shows that multiple YTHDF readers redundantly regulate progenitor fate and body size.

Chemical inhibition of Exon Junction Complex assembly impairs mRNA localization and neural stem cells ciliogenesis

This study shows that inhibiting EJC assembly with EJC-i disrupts mRNA localization and neural stem cell ciliogenesis by affecting multiple post-transcriptional processes.

Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

The paper introduces a differential model m6ADyn to predict m6A dynamics by integrating mRNA metabolism and validates its predictions through experimental confirmation.

Pus7 mutation links tRNA dysregulation to aggressive behavior through activation of the integrated stress response and glycolytic reprogramming

The paper shows that Pus7 mutations reduce tRNA-Asp levels, activating the integrated stress response and glycolytic reprogramming, which contributes to aggressive behavior.

Transfer RNA acetylation regulates in vivo mammalian stress signaling

This study shows that tRNA acetylation regulates stress signaling in mammals by affecting ribosome function and interacting with the Gcn2 kinase.

A sequence-specific RNA acetylation catalyst

This study characterizes TkNat10, an RNA acetyltransferase from T. kodakarensis, showing its role in thermotolerance and its ability to modify RNA substrates with specific sequence preferences.

txtools: an R package facilitating analysis of RNA modifications, structures, and interactions

txtools is an R package that processes and analyzes RNA-seq data at the nucleotide level, providing tools for visualization and downstream analysis in epitranscriptomics and structural mapping.

The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles

The paper identifies three novel components of the yeast m6A methyltransferase complex and reveals their distinct m6A-dependent and independent roles in meiosis and mating.

m6A is required for resolving progenitor identity during planarian stem cell differentiation

This study shows that m6A modification is essential for planarian stem cell differentiation and tissue regeneration by regulating histone variant transcription and chromatin modifications.

Exon-intron architecture determines mRNA stability by dictating m6A deposition

The paper shows that m6A methylation is excluded near exon-intron junctions and is determined by m6A motifs and exon-intron architecture, linking mRNA stability to splicing memory.

A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit

This study identifies a late-stage quality control step in human mitochondrial ribosome large subunit assembly, showing that MRM2 ablation impairs oxidative phosphorylation through defective translation and accumulation of assembly intermediates.

Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution

The paper investigates the role of SNORD13 in rRNA acetylation across eukaryotes, showing its requirement in human and zebrafish but not in yeast or C. elegans.

Quantitative profiling of native RNA modifications and their dynamics using nanopore sequencing

The paper introduces a method to quantify RNA modifications using nanopore sequencing, revealing novel modification sites and dynamics in yeast under environmental stress.

Accurate detection of m6A RNA modifications in native RNA sequences

This paper demonstrates the detection of m6A RNA modifications in native RNA sequences using Oxford Nanopore Technologies with high accuracy.

Deciphering the ‘m6A code’ via quantitative profiling of m6A at single-nucleotide resolution

This paper introduces MASTER-seq, a method to quantitatively profile m6A sites at single-nucleotide resolution, revealing a predictable code that determines m6A stoichiometry and dynamics.

M1A within cytoplasmic mRNAs at single nucleotide resolution: A reconciled transcriptome-wide map

This paper reconciles conflicting findings on m1A modification in cytosolic mRNAs by reanalyzing data, revealing most sites are artifacts and only 53 are genuine internal modifications, primarily catalyzed by TRMT6/TRMT61A at low levels.