Leonor Miller‐Fleming

Clu1/Clu form mitochondria-associated granules upon metabolic transitions and regulate mitochondrial protein translation via ribosome interactions

This study shows that Clu/Clu1 proteins form mitochondrial-associated granules and regulate mitochondrial protein translation by interacting with ribosomes and mRNAs during metabolic transitions.

Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction in C9orf72 ALS/FTD in vivo models and patient iNeurons

This study shows that activating the Keap1/Nrf2 pathway reduces mitochondrial dysfunction and motor deficits in C9orf72 ALS/FTD models and patient-derived neurons.

A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit

This study identifies a late-stage quality control step in human mitochondrial ribosome large subunit assembly, showing that MRM2 ablation impairs oxidative phosphorylation through defective translation and accumulation of assembly intermediates.

A Yeast Global Genetic Screen Reveals that Metformin Induces an Iron Deficiency-Like State

The paper uses hdPCA to identify gene functions and pathways affected by metformin, revealing an iron deficiency-like cellular response.