Author

Kyle C. Dent

MRC Laboratory of Molecular Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metagenomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam M. DinaniD· 1 shared Alan John WarreniD· 1 shared Aldema Sas‐CheniD· 1 shared Alexander J. WhitworthiD· 1 shared Andrew E. FirthiD· 1 shared Byron AndrewsiD· 1 shared Caterina GaroneiD· 1 shared Christopher J. RussoiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Adam M. DinanORCID

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2 papers

Recent·Most cited

A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit

Pedro Rebelo‐Guiomar, Simone Pellegrino, Kyle C. Dent, Aldema Sas‐Chen, Leonor Miller‐Fleming, Caterina Garone, Lindsey Van Haute, Jack F. Rogan, Adam M. Dinan, Andrew E. Firth, Byron Andrews, Alexander J. Whitworth, Schraga Schwartz, Alan John Warren, Michal A. Minczuk

This study identifies a late-stage quality control step in human mitochondrial ribosome large subunit assembly, showing that MRM2 ablation impairs oxidative phosphorylation through defective translation and accumulation of assembly intermediates.

Nature Communications · Feb 17, 2022Peer-reviewedMolecular Biology

Structural basis for the inhibition of the SARS-CoV-2 RNA-dependent RNA polymerase by favipiravir-RTP

Katerina Naydenova, Kyle Muir, Long-Fei Wu, Ziguo Zhang, Francesca Coscia, Mathew James Peet, Pablo Castro‐Hartmann, Qian Pu, Kasim Sader, Kyle C. Dent, Dari Kimanius, John D. Sutherland, Jan Löwe, David Barford, Christopher J. Russo

This study determines the structure of favipiravir-RTP bound to SARS-CoV-2 RdRp, revealing its weak incorporation mechanism and low replication suppression.

bioRxiv · Oct 21, 2020 · PreprintMolecular Biology