A scalable long-term in vitro model of human colonic epithelium with continuous barrier function
Ashley J. Cuttitta, Sophia R. Meyer, Tristan Frum, Bhargavasai Gunuguntla, Angeline Wu, Sha Huang, Jack Morgan, Michael K. Dame, Jonathan Z. Sexton, Jason R. Spence
This paper develops a long-term in vitro model of human colonic epithelium that maintains barrier function for up to 30 days and responds to various challenges.
bioRxiv · Sep 24, 2025 · PreprintCell Biology