Michael K. Dame

The paper constructs a developmental cell atlas of the human esophagus and develops in vitro models that recapitulate esophageal architecture, revealing WNT2B's role in regulating basal progenitor self-renewal.

This study identifies RUNX2 as a regulator of WNT signaling in UC by analyzing snRNA-seq and snATAC-seq data from UC patient-derived colonoids.

This paper develops a long-term in vitro model of human colonic epithelium that maintains barrier function for up to 30 days and responds to various challenges.

The paper uses ChRO-seq to study chromatin dynamics during human small intestinal development, identifying enhancer activity and transcription patterns at HOX gene loci.

This study shows that normal human colonoids differentiate in low calcium and that calcium or Aquamin further enhances adhesion and barrier proteins.