Author

Jacob A. Medjo

Seattle Children's Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron B.I. RoseniD· 1 shared Dane A. Grosvenor· 1 shared David J. RawlingsiD· 1 shared Denny LiggittiD· 1 shared Eric J. AllenspachiD· 1 shared Jane Hoyt BuckneriD· 1 shared Kimberly A. Dill‐McFarlandiD· 1 shared Matthew A. MacQuiveyiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Aaron B.I. RosenORCID

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1 paper

Recent·Most cited

Reduced function of the adaptor SH2B3 promotes T1D via altered γc cytokine-regulated, T cell intrinsic immune tolerance

Taylor K. Watson, Aaron B.I. Rosen, Travis Drow, Jacob A. Medjo, Matthew A. MacQuivey, Yan Ge, Denny Liggitt, Dane A. Grosvenor, Kimberly A. Dill‐McFarland, Matthew C. Altman, PATRICK J. CONCANNON, Jane Hoyt Buckner, David J. Rawlings, Eric J. Allenspach

This study identifies SH2B3 as a critical regulator of T cell tolerance in T1D, showing that its deficiency enhances cytokine signaling and promotes islet destruction.

Diabetes · Mar 6, 2025Peer-reviewedImmunology