ImmunologyDiabetesPeer-reviewed
Reduced function of the adaptor SH2B3 promotes T1D via altered γc cytokine-regulated, T cell intrinsic immune tolerance
Taylor K. Watson, Aaron B.I. Rosen, Travis Drow…·Eric J. Allenspach
This study identifies SH2B3 as a critical regulator of T cell tolerance in T1D, showing that its deficiency enhances cytokine signaling and promotes islet destruction.
4 citations