Aaron B.I. Rosen

This study identifies SH2B3 as a critical regulator of T cell tolerance in T1D, showing that its deficiency enhances cytokine signaling and promotes islet destruction.

This study shows the IFIH1-A946T risk variant increases T1D risk in females but not males by enhancing IFN I signaling and altering immune cell profiles in NOD mice.

SLIDE identifies significant interacting latent factors in multi-omic datasets, revealing biological insights in systemic sclerosis, spatial transcriptomics, and T1D models.