Kimberly A. Dill‐McFarland

This study compares human and murine macrophage responses to Mtb infection, identifying shared and distinct immune pathways and cytokine expression patterns between alveolar and monocyte-derived macrophages.

This study investigates itaconate's role in human macrophages, showing distinct effects in alveolar-like and M-CSF-derived macrophages during M. tuberculosis infection.

The paper integrates multi-omic data to identify latent factors associated with resistance to TB conversion, revealing pathways related to multicellular structure and cell-cell interactions.

This study identifies genetic risk factors for tuberculosis in Brazil using GWAS and single-cell transcriptomics, finding SNPs associated with gene expression in multiple cell types.

This study identifies SH2B3 as a critical regulator of T cell tolerance in T1D, showing that its deficiency enhances cytokine signaling and promotes islet destruction.

The paper identifies epigenetic methylation differences in lipid and cholesterol pathways associated with resistance to TST/IGRA conversion after Mtb exposure.

This study compares transcriptional responses of human alveolar macrophages and monocyte-derived macrophages to Mtb infection, identifying distinct gene expression patterns and pathways.

kimma is an R package for linear mixed effects modeling of RNA-seq data, offering improved sensitivity and model complexity compared to existing pipelines.