Co-targeting the PI3K-Akt pathway improves response to MEK inhibition in low-grade serous ovarian cancer cell lines
Rebekah M. Peplinski, Jesse D. Riordan, Jacob L. Schillo, Elizabeth C. Hannan, Silvana Pedra Nobre, Yasmin A. Lyons, Keely Ulmer, Michael Joseph Goodheart, Adam J. Dupuy
This study shows that combining MEK and PI3K-Akt inhibition enhances anti-tumor effects in LGSOC cells and may overcome resistance to MEK inhibitors.
Gynecologic Oncology · Dec 5, 2025Peer-reviewedCancer Biology