Author

Silvana Pedra Nobre

University of IowaORCID 0000-0002-3729-8790Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Adam J. DupuyiD· 1 shared Elizabeth C. HannaniD· 1 shared Jacob L. Schillo· 1 shared Jesse D. RiordaniD· 1 shared Keely UlmeriD· 1 shared Michael Joseph GoodheartiD· 1 shared Rebekah M. PeplinskiiD· 1 shared Yasmin A. LyonsiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperCancer Biology

Adam J. DupuyORCID

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1 paper

Recent·Most cited

Co-targeting the PI3K-Akt pathway improves response to MEK inhibition in low-grade serous ovarian cancer cell lines

Rebekah M. Peplinski, Jesse D. Riordan, Jacob L. Schillo, Elizabeth C. Hannan, Silvana Pedra Nobre, Yasmin A. Lyons, Keely Ulmer, Michael Joseph Goodheart, Adam J. Dupuy

This study shows that combining MEK and PI3K-Akt inhibition enhances anti-tumor effects in LGSOC cells and may overcome resistance to MEK inhibitors.

Gynecologic Oncology · Dec 5, 2025Peer-reviewedCancer Biology