TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and Macrophages
Chelsea Joy Webber, Sophie J. F. van der Spek, Anna Lourdes Cruz, Sambhavi Puri, Cheng Zhang, Jacqueline T. M. Aw, Georgia-Zeta Papadimitriou, Rebecca Roberts, Kiki Jiang, Thai Tran, Lushuang Zhang, Alexandria Taylor, Zihan Wang, Jacob Porter, Ioannis Sotiropoulos, , Benjamin L. Wolozin
This study shows TIA1 regulates divergent inflammatory responses in microglia and macrophages, reducing brain inflammation and tau pathology while increasing peripheral inflammation.
bioRxiv · Nov 6, 2024 · PreprintNeuroscience