Lushuang Zhang

This study shows TIA1 regulates divergent inflammatory responses in microglia and macrophages, reducing brain inflammation and tau pathology while increasing peripheral inflammation.

The paper uses proximity labeling to study the dynamic SQSTM1 protein network and shows that aggregated tau alters its interactions with stress-associated proteins.

This study shows that m6A accumulation correlates more strongly with MAPT pathology than beta-amyloid in an Alzheimer's mouse model.

The paper develops a 3D neuron-astrocyte coculture model to study tauopathy, showing it recapitulates pathological features and responds to HSP90 inhibitor treatment.