Rebecca Roberts

Progressive Remodeling of Global Protein Interaction Networks in a Mouse Model of Tauopathy

The paper maps protein interaction network remodeling in a mouse tauopathy model using multi-omics and machine learning, identifying key complexes involved in early disease phenotypes.

Modeling Alzheimer's Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic Targets

The paper develops a 3D brain assembloid model to study Alzheimer's disease progression and identifies IGFBP pathways as therapeutic targets in APOE4 carriers.

Tau Oligomerization Drives Neurodegeneration via Nuclear Membrane Invagination and Lamin B Receptor Binding in Alzheimer's disease

This study shows that tau oligomerization causes nuclear membrane invagination and lamina disruption in Alzheimer's disease, linking nuclear stress to neurodegeneration.

TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and Macrophages

This study shows TIA1 regulates divergent inflammatory responses in microglia and macrophages, reducing brain inflammation and tau pathology while increasing peripheral inflammation.

Accumulation of m6A exhibits stronger correlation with MAPT than beta-amyloid pathology in an APP NL-G-F /MAPT P301S mouse model of Alzheimer's disease

This study shows that m6A accumulation correlates more strongly with MAPT pathology than beta-amyloid in an Alzheimer's mouse model.