Author

Jacob S. Brenner

University of PennsylvaniaPrimary ORCID profile (0000-0001-8437-0161 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Jacob S. BrenneriD1 paper

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Jacob W. MyersoniD· 2 shared Jia NongiD· 2 shared Jichuan WuiD· 2 shared Oscar Armando Marcos-ContrerasiD· 2 shared Vladimir R. MuzykantoviD· 2 shared Alireza Ebrahimimojarad· 1 shared Andrew Hanna· 1 shared Carolann L. EspyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiophysics

Jacob W. MyersonORCID

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2 papers

Recent·Most cited

A percolation-type criticality threshold controls immune protein coating of surfaces

Zhicheng Wang, Sahil Kulkarni, Jia Nong, Marco E. Zamora, Alireza Ebrahimimojarad, Elizabeth D. Hood, Tea Shuvaeva, Michael H. Zaleski, Damodar Gullipalli, Emily Wolfe, Carolann L. Espy, Evguenia Arguiri, Jichuan Wu, Yufei Wang, Oscar Armando Marcos-Contreras, , Jacob S. Brenner

The paper identifies a critical threshold in complement activation based on surface density, showing percolation-type behavior in immune responses to materials.

Cell · Jun 13, 2025Peer-reviewedBiophysics

Multi-stage-mixing to control the supramolecular structure of lipid nanoparticles, thereby creating a core-then-shell arrangement that improves performance by orders of magnitude

Jia Nong, Xijing Gong, Quang Minh Dang, Sachchidanand Tiwari, Manthan N. Patel, Jichuan Wu, Andrew Hanna, W. Park, Elena N. Atochina‐Vasserman, Hui-Ting Huang, Oscar Armando Marcos-Contreras, Kahlilia C. Morris-Blanco, Jonathan J. Miner, Drew Weissman, Vladimir R. Muzykantov, , Jacob S. Brenner

This paper introduces multi-stage-mixing (MSM) to control lipid nanoparticle (LNP) supramolecular structure, creating a core-then-shell arrangement that significantly improves mRNA and DNA-LNP performance.

bioRxiv · Nov 12, 2024 · PreprintBioengineering