Multi-stage-mixing to control the supramolecular structure of lipid nanoparticles, thereby creating a core-then-shell arrangement that improves performance by orders of magnitude
Jia Nong, Xijing Gong, Quang Minh Dang, Sachchidanand Tiwari, Manthan N. Patel, Jichuan Wu, Andrew Hanna, W. Park, Elena N. Atochina‐Vasserman, Hui-Ting Huang, Oscar Armando Marcos-Contreras, Kahlilia C. Morris-Blanco, Jonathan J. Miner, Drew Weissman, Vladimir R. Muzykantov, , Jacob S. Brenner
This paper introduces multi-stage-mixing (MSM) to control lipid nanoparticle (LNP) supramolecular structure, creating a core-then-shell arrangement that significantly improves mRNA and DNA-LNP performance.
bioRxiv · Nov 12, 2024 · PreprintBioengineering