Jacob W. Myerson

Nanoparticle Albumin-Bound Paclitaxel Targets Pulmonary Neutrophils

This paper identifies pulmonary neutrophils as the primary target of Abraxane in lung cancer and shows that its efficacy depends on complement pathway-mediated lung uptake.

Percolation-inspired criticality in complement activation: universal scaling and transport-limited complement surface amplification

This study investigates complement activation on nanoparticle surfaces, showing it exhibits criticality with diverging order parameters and a transport-limited mechanism.

Tropomyosin 1 promotes platelet adhesion and clot contraction separate from its roles in developmental hematopoiesis

This study shows Tpm1 promotes platelet adhesion and clot contraction independently of its role in embryonic hematopoiesis, linking it to thrombotic disease risk.

Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

This study shows that targeting DNA-LNPs to endothelial cells enhances transgene expression magnitude, duration, and specificity in target organs.

A percolation-type criticality threshold controls immune protein coating of surfaces

The paper identifies a critical threshold in complement activation based on surface density, showing percolation-type behavior in immune responses to materials.

Multi-stage-mixing to control the supramolecular structure of lipid nanoparticles, thereby creating a core-then-shell arrangement that improves performance by orders of magnitude

This paper introduces multi-stage-mixing (MSM) to control lipid nanoparticle (LNP) supramolecular structure, creating a core-then-shell arrangement that significantly improves mRNA and DNA-LNP performance.

Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial system

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.

Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape without Side Effects

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.