Jonathan J. Miner

This study shows CD14-deficiency protects against osteoarthritis-related subchondral bone sclerosis by enhancing osteoclastogenesis post-injury in mice.

This study establishes a Drosophila model of RVCL-S that recapitulates disease features, showing vascular deterioration and reduced lifespan in TREX1 mutant flies.

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

This paper introduces multi-stage-mixing (MSM) to control lipid nanoparticle (LNP) supramolecular structure, creating a core-then-shell arrangement that significantly improves mRNA and DNA-LNP performance.