Author

Jacqueline Lypowy

Pfizer (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Arthur Illenberger· 2 shared Christopher Ponce· 2 shared Laurent Chorro· 2 shared Natalie C. Silmon de MonerriiD· 2 shared Robert G. K. DonaldiD· 2 shared Alexandre Esadze· 1 shared Alexey V. GribenkoiD· 1 shared Annalena La Porte· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Arthur Illenberger

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Improving the immunogenicity of E. coli FimH via multivalent display on I53-50 nanoparticles

Rebecca S Cole, Natalie C. Silmon de Monerri, Jacqueline Lypowy, Christopher Ponce, Cara Kobylarz, L Liu, Zein Kasbo, Elizabeth Kepl, Tara Ciolino, Arthur Illenberger, Leslie Gallardo, Annalena La Porte, Danielle E. Baranova, Rashmi Ravichandran, Laurent Chorro, , Neil P. King

This paper improves the immunogenicity of E. coli FimH by displaying it on I53-50 nanoparticles, achieving comparable antibody responses to higher doses of monomeric FimH with reduced adjuvant needs.

Frontiers in Immunology · Jul 21, 2026Peer-reviewedImmunology

Structure-Based Design of a Highly Immunogenic, Conformationally Stabilized FimH Antigen for a Urinary Tract Infection Vaccine

Natalie C. Silmon de Monerri, Ye Che, Joshua A. Lees, J. Jasti, Huixian Wu, Matthew C. Griffor, Srinivas Kodali, Julio Cesar Hawkins, Jacqueline Lypowy, Christopher Ponce, Kieran Curley, Alexandre Esadze, Juan Guillermo Cárcamo, Thomas McLellan, David R. Keeney, , Robert G. K. Donald

The paper designs a conformationally stabilized FimH antigen for a UTI vaccine, showing improved immunogenicity and structural similarity to native FimH.

PLoS Pathogens · Feb 19, 2025Peer-reviewedMicrobiology