A FMRF-amide peptide that regulates cell non-autonomous protein homeostasis in C. elegans.
Carrie A. Sheeler, Jacqueline Y. Lo, Daviana Menendez Escalera, Emmett Griffin‐Baldwin, Karmen Mah, Adam Roszczyk, Antoine E. Roux, Cynthia J. Kenyon, Jennifer L. Garrison, Ashley E. Frakes
This study identifies FLP-17, a neuropeptide that mediates cell non-autonomous UPRER activation in C. elegans, protecting against ER stress and protein aggregation.
bioRxiv · Mar 14, 2025 · PreprintNeuroscience