Jennifer L. Garrison

Oxytocin-like signaling couples reproductive state to intestinal lipid metabolism in aging C. elegans

This study shows that nematocin, an oxytocin/vasopressin-like neuropeptide in C. elegans, regulates intestinal lipid metabolism and reproductive output during aging.

Aging disrupts spatiotemporal coordination in the cycling murine ovary

This study uses spatial transcriptomics to show that aging disrupts spatial and temporal coordination of folliculogenesis in mouse ovaries, leading to tissue disorganization and reproductive decline.

A FMRF-amide peptide that regulates cell non-autonomous protein homeostasis in C. elegans.

This study identifies FLP-17, a neuropeptide that mediates cell non-autonomous UPRER activation in C. elegans, protecting against ER stress and protein aggregation.

Dysregulation of the fluid homeostasis system by aging

This study investigates how aging affects fluid homeostasis in mice, finding that older mice have impaired vasopressin production and altered thirst circuitry responses to dehydration cues.

A role for worm cutl-24 in background- and parent-of-origin-dependent ER stress resistance

The paper identifies cutl-24 as a gene responsible for ER stress resistance in a Kenyan C. elegans isolate, showing parent-of-origin effects and validating its role through genetic experiments.