Charge Screening by Extracellular Ca2+ Shields Endothelial Cells from Histone Injury and Permits Membrane Repair
Jade H. Cleary, Kara J. Wentzel, Abigail J. Howard, Adrian M. Sackheim, Sophia H. Piffard, Rushi Sonawane, Mohamed S. Ahmed, Lydia Sheeser, J. Cory Benson, Grant W. Hennig, Dev Majumdar, Mohamed Trebak, Mark T. Nelson, Kalev Freeman
The paper investigates how extracellular Ca2+ shields endothelial cells from histone-induced injury and enables membrane repair through direct interaction with histones and membrane phospholipids.
bioRxiv · Jul 13, 2025 · PreprintPhysiology