Author

Adrian M. Sackheim

University of Vermont

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:imaging· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Organism:human· 1

Frequent Co-Authors

Grant W. HennigiD· 3 shared Kalev FreemaniD· 3 shared Mark T. NelsoniD· 3 shared Devdoot S. MajumdariD· 2 shared Mohamed TrebakiD· 2 shared Rushi SonawaneiD· 2 shared Abigail J. Howard· 1 shared Amreen MughaliD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersPhysiology

Grant W. HennigORCID

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Author profile →

3 papers

Recent·Most cited

Spatial uncoupling of endothelial calcium signaling from phosphatidylserine externalization in vascular injury

Olivia Fauver, Grant W. Hennig, Adrian M. Sackheim, Bryan Walters, Rachel Barba, Rushi Sonawane, Christopher Bidlack, Devdoot S. Majumdar, Mohamed Trebak, Mark T. Nelson, Kalev Freeman

This study shows that endothelial calcium signaling spreads widely during vascular injury, but phosphatidylserine externalization remains localized, revealing spatial uncoupling between calcium signaling and phospholipid scrambling.

bioRxiv · Oct 24, 2026 · PreprintPhysiology

Charge Screening by Extracellular Ca2+ Shields Endothelial Cells from Histone Injury and Permits Membrane Repair

Jade H. Cleary, Kara J. Wentzel, Abigail J. Howard, Adrian M. Sackheim, Sophia H. Piffard, Rushi Sonawane, Mohamed S. Ahmed, Lydia Sheeser, J. Cory Benson, Grant W. Hennig, Dev Majumdar, Mohamed Trebak, Mark T. Nelson, Kalev Freeman

The paper investigates how extracellular Ca2+ shields endothelial cells from histone-induced injury and enables membrane repair through direct interaction with histones and membrane phospholipids.

bioRxiv · Jul 13, 2025 · PreprintPhysiology

Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature

Kalev Freeman, Adrian M. Sackheim, Amreen Mughal, Masayo Koide, Grace Bonson, Grace Ebner, Grant W. Hennig, Warren E. Lockette, Mark T. Nelson

This study shows that pathogenic tau peptides reduce endothelial calcium signaling and vasodilation in brain microvessels, impairing cerebral blood flow.

bioRxiv · Aug 8, 2023 · PreprintNeuroscience