Neurogenesis-mediated circuit remodeling reduces engram reinstatement and promotes forgetting
Axel J. Guskjolen, Jagroop Dhaliwal, Juan de la Parra, Jonathan R. Epp, Sangyoon Y. Ko, Erin R. Chahley, Mitchell L. de Snoo, Michela Solari, Prabdeep Panesar, Jason S. Snyder, Xin Duan, Joshua R. Sanes, Sheena A. Josselyn, Paul W. Frankland
The paper shows that hippocampal neurogenesis remodeling causes forgetting by altering engram accessibility, using genetic and optogenetic manipulations in mice.
bioRxiv · Oct 10, 2023 · PreprintNeuroscience