Sangyoon Y. Ko

The paper curates 222 genes associated with autism spectrum disorder (ASD) using the EAGLE framework, identifying 78 with definitive evidence and highlighting differential expression patterns between ASD and broader neurodevelopmental disorders.

This study shows that reducing somatic CAG expansions in HD mice improves motor function and disease markers, suggesting therapeutic potential for HD and similar repeat expansion diseases.

The paper identifies DDX53 genetic variants in individuals with ASD, showing a link between DDX53 and ASD, and highlights implications for genetic testing and mouse modeling.

The paper shows that hippocampal neurogenesis remodeling causes forgetting by altering engram accessibility, using genetic and optogenetic manipulations in mice.

This study shows that the maturation of hippocampal inhibitory interneurons by extracellular matrix is necessary for the development of precise episodic-like memories in mice.