Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes
Madeline G. Andrews, Tanzila Mukhtar, Ugomma C. Eze, Camille R. Simoneau, Yonatan Perez, Mohammed A. Mostajo-Radji, Shaohui Wang, Dmitry Velmeshev, Jahan Salma, G. Renuka Kumar, Alex A. Pollen, Elizabeth Erin Crouch, Mélanie Ott, Arnold R. Kriegstein
In primary human cortical tissue and stem cell-derived organoids, SARS-CoV-2 infects astrocytes almost exclusively, apparently through DPP4 rather than ACE2, leaving them reactive and stressed.
bioRxiv · Jan 17, 2021 · PreprintNeuroscience