Madeline G. Andrews

The paper creates a microglia forebrain assembloid to study human brain development and neuroimmune interactions, showing microglia's role in cortex formation and metabolic changes.

This study shows that physiologic glucose and oxygen levels influence human cortical development by altering metabolic states and cell fate decisions in organoids.

This study shows that the identity of MGE-derived cortical interneurons can be dynamically influenced by their environment, with human 3D models promoting Pvalb expression over Sst.

The paper identifies the pentose phosphate pathway's role in regulating radial glia cell fate during human cortical development using metabolic assays and genetic manipulations.

The paper creates a single-cell multi-omic atlas of the rhesus macaque brain, identifying cell-type-specific regulatory elements and providing insights into brain evolution and disease.

In primary human cortical tissue and stem cell-derived organoids, SARS-CoV-2 infects astrocytes almost exclusively, apparently through DPP4 rather than ACE2, leaving them reactive and stressed.

This study shows that mTOR signaling regulates the morphology and migration of outer radial glia in the developing human cortex by affecting the actin cytoskeleton through CDC42.

The paper uses chimpanzee cerebral organoids to identify human-specific genes in cortical development and finds increased PI3K/AKT/mTOR activation in human outer radial glia.