Shaohui Wang

Receptor-binding domain 2 of Clostridioides difficile binary toxin as a promising vaccine component against C. difficile infection

This study identifies RBD2 of C. difficile binary toxin as a promising vaccine component that provides protection against CDT-mediated infection in animal models.

A multimodal interrogation of Broca's area in the pediatric and adult human brain

The paper provides a high-resolution molecular and cellular analysis of Broca's area and motor cortex across developmental stages, identifying distinct cellular signatures and vulnerabilities to neurodevelopmental disorders.

Progenitor Diversity and Architecture of the Human Ganglionic Eminences Shaping the Basal Ganglia

The paper identifies distinct progenitor populations in human ganglionic eminences, their gene regulatory networks, and lineage trajectories using single-nucleus transcriptomics and spatial transcriptomics.

Single cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism

This study uses single-cell analysis of dup15q syndrome to identify developmental and postnatal molecular changes in autism, revealing cell-type specific dysregulation and shared vulnerabilities with idiopathic ASD.

α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex

This study shows that α7 nicotinic acetylcholine receptors influence radial glia fate in human cortical development, with nicotine exposure altering neuronal differentiation and RG proliferation.

Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

This study maps the molecular and cellular dynamics of the developing human neocortex using single-nucleus data, revealing gene regulatory networks and a cancer-related progenitor subtype.

Spatial dynamics of mammalian brain development and neuroinflammation by multimodal tri-omics mapping

Spatial tri-omic sequencing (DBiT ARP-seq and DBiT CTRP-seq) and CODEX imaging map chromatin, RNA, and protein dynamics across mammalian brain development and lysolecithin-induced neuroinflammation.

Single-cell analysis of prenatal and postnatal human cortical development

The paper constructs a single-cell transcriptomic atlas of human cortical development, identifying lineage and sex-specific gene expression programs linked to autism risk.

A cross-species proteomic map reveals neoteny of human synapse development

This study creates a cross-species proteomic map of synapse development in human, macaque, and mouse neocortex, revealing slower human PSD maturation and its potential link to neoteny.

Molecular diversity and lineage commitment of human interneuron progenitors

The paper identifies molecular subtypes of human interneuron progenitors and immature interneurons using single-cell RNA sequencing and compares them to mouse data, revealing species-specific gene programs.

Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes

In primary human cortical tissue and stem cell-derived organoids, SARS-CoV-2 infects astrocytes almost exclusively, apparently through DPP4 rather than ACE2, leaving them reactive and stressed.