Recurrent RNA-lipoplex vaccination is required to sustain functional tumor-infiltrating neoantigen-specific CD8 T cells and therapeutic efficacy
Justin Tyler Gibson, Milena Hornburg, Sophie M. Lehar, Vincent Javinal, Lisa Liao, Mark J. McCarron, Tamaki Nozawa Jones, Yoko A. Oei, Debra Y. Dunlap, Kevin A. Marroquin, Amy A. Lo, Jan H. Bergmann, Ann-Jay Tong, Ariane Nissenbaum, Emily C. Freund, , Lélia Delamarre
This study shows that repeated RNA-lipoplex vaccination sustains functional CD8 T cells in tumors and improves therapeutic outcomes.
bioRxiv · Nov 16, 2025 · PreprintImmunology