Author

Ann-Jay Tong

GenentechORCID 0009-0003-8793-8025Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Emily C. FreundiD· 2 shared Ira MellmaniD· 2 shared Jill M. Schartner· 2 shared Lélia DelamarreiD· 2 shared Mark J. McCarroniD· 2 shared Milena Hornburg· 2 shared Sophie M. Lehar· 2 shared Vincent Javinal· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Emily C. FreundORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintNov 16, 2025

Recurrent RNA-lipoplex vaccination is required to sustain functional tumor-infiltrating neoantigen-specific CD8 T cells and therapeutic efficacy

Justin Tyler Gibson, Milena Hornburg, Sophie M. Lehar…·Lélia Delamarre

This study shows that repeated RNA-lipoplex vaccination sustains functional CD8 T cells in tumors and improves therapeutic outcomes.

DOI 10.1101/2025.11.16.687774

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 26, 2025

Cross-competition shapes CD8+ T cell hierarchies and differentiation after RNA vaccination

Mark J. McCarron, Milena Hornburg, Thomas D. Wu…·Lélia Delamarre

The paper investigates how immunodominance affects CD8+ T cell differentiation and hierarchy after RNA vaccination, finding that dominant responses influence subdominant ones through cross-competition.

5 citations

humanbulk RNA-seq

𝕏 PostBluesky