Author

Mark J. McCarron

Regeneron (United States)ORCID 0000-0001-9907-2845Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Ann-Jay TongiD· 2 shared Emily C. FreundiD· 2 shared Ira MellmaniD· 2 shared Jill M. Schartner· 2 shared Lélia DelamarreiD· 2 shared Milena Hornburg· 2 shared Sophie M. Lehar· 2 shared Vincent Javinal· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Ann-Jay TongORCID

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2 papers

Recent·Most cited

Recurrent RNA-lipoplex vaccination is required to sustain functional tumor-infiltrating neoantigen-specific CD8 T cells and therapeutic efficacy

Justin Tyler Gibson, Milena Hornburg, Sophie M. Lehar, Vincent Javinal, Lisa Liao, Mark J. McCarron, Tamaki Nozawa Jones, Yoko A. Oei, Debra Y. Dunlap, Kevin A. Marroquin, Amy A. Lo, Jan H. Bergmann, Ann-Jay Tong, Ariane Nissenbaum, Emily C. Freund, , Lélia Delamarre

This study shows that repeated RNA-lipoplex vaccination sustains functional CD8 T cells in tumors and improves therapeutic outcomes.

bioRxiv · Nov 16, 2025 · PreprintImmunology

Cross-competition shapes CD8+ T cell hierarchies and differentiation after RNA vaccination

Mark J. McCarron, Milena Hornburg, Thomas D. Wu, Ann-Jay Tong, Siri Tähtinen, Martine Darwish, Emily C. Freund, Ying Feng, David Eisel, Camille-Charlotte Balança, Itai Doron, Huan Lan, Sophie M. Lehar, Tamaki Nozawa, Yoko A. Oei, , Lélia Delamarre

The paper investigates how immunodominance affects CD8+ T cell differentiation and hierarchy after RNA vaccination, finding that dominant responses influence subdominant ones through cross-competition.

bioRxiv · Oct 26, 2025 · PreprintImmunology