Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
Matthias Thoms, Robert Buschauer, Michael Ameismeier, Lennart Koepke, Timo Denk, Maximilian Hirschenberger, Hanna Kratzat, Manuel Hayn, Timur Mackens‐Kiani, Jingdong Cheng, Jan Hendrik Straub, Christina Martina Stürzel, Thomas Fröhlich, Otto Berninghausen, Thomas A. Becker, , Roland Beckmann
This study reveals how SARS-CoV-2 Nsp1 protein inhibits host translation and immune responses by binding ribosomes and blocking mRNA entry.
Science · Jul 17, 2020Peer-reviewedMolecular Biology