Timur Mackens‐Kiani

This study shows that MutS2 in B. subtilis splits stalled ribosomes into subunits without cleaving mRNA, differing from the E. coli SmrB mechanism.

The paper uses cryo-EM to characterize native ABCE1-containing pre-initiation complexes in yeast and human cells, revealing their structural roles in translation initiation.

The paper presents cryo-EM structures of hibernating yeast and human ribosomes, showing Lso2/CCDC124 binds in a non-rotated state, enabling rapid translation reactivation.

This study reveals how SARS-CoV-2 Nsp1 protein inhibits host translation and immune responses by binding ribosomes and blocking mRNA entry.