Nanoparticle encapsulation enhances spatial distribution of Panobinostat to treat metastatic medulloblastoma via the intrathecal route
Oluwatobi Helen Babayemi, Jon D. Larson, Sauradip Chaudhuri, Fred Valesquez, Janelle Morton, Chung-Fan Kuo, Lindsey K. Sablatura, Gerard Baquer, Michael S Reagan, Sylwia A. Stopka, David I. Sandberg, Nathalie Y.R. Agar, Eva Marie Sevick-Muraca, Robert J. Wechsler‐Reya, Rachael W. Sirianni
This study develops a nanoparticle system to deliver Panobinostat intrathecally for treating metastatic medulloblastoma, showing improved drug distribution and survival benefits in mice.
bioRxiv · Apr 2, 2026 · PreprintBioengineering