Eva Marie Sevick-Muraca

Turep: Detecting cross-cancer tumor-reactive T cells in single-cell and spatial transcriptomics data

Turep identifies tumor-reactive T cells in single-cell and spatial transcriptomics data across cancers, showing improved prediction of immunotherapy response.

Nanoparticle encapsulation enhances spatial distribution of Panobinostat to treat metastatic medulloblastoma via the intrathecal route

This study develops a nanoparticle system to deliver Panobinostat intrathecally for treating metastatic medulloblastoma, showing improved drug distribution and survival benefits in mice.

An EPHB4-RASA1 signaling complex inhibits shear stress-induced Ras-MAPK activation in lymphatic endothelial cells to promote the development of lymphatic vessel valves