Enhanced BCMA Antigen Density Increases Trogocytosis and Attenuates CAR T cell Function
Pınar Ataca Atilla, Sylvain Simon, Erden Atilla, David Glen Coffey, Andrew J. Cowan, Grace Bugos, Thomas Diefenbach, Janice J Huang, Efe Karaca, Zhiqun Zhou, Melissa Comstock, Geoffrey R. Hill, Stanley R. Riddell, Damian J. Green
This study shows that increasing BCMA density with GSI improves CAR T cell cytotoxicity but also enhances trogocytosis, leading to CAR T cell dysfunction and exhaustion.
bioRxiv · Jul 16, 2026 · PreprintCancer Biology