Author

Thomas Diefenbach

University of MiamiORCID 0000-0002-2798-5909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew J. CowaniD· 1 shared Damian J. GreeniD· 1 shared David Glen CoffeyiD· 1 shared Efe KaracaiD· 1 shared Erden AtillaiD· 1 shared Geoffrey R. HilliD· 1 shared Grace BugosiD· 1 shared Janice J Huang· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Andrew J. CowanORCID

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1 paper

Recent·Most cited

Enhanced BCMA Antigen Density Increases Trogocytosis and Attenuates CAR T cell Function

Pınar Ataca Atilla, Sylvain Simon, Erden Atilla, David Glen Coffey, Andrew J. Cowan, Grace Bugos, Thomas Diefenbach, Janice J Huang, Efe Karaca, Zhiqun Zhou, Melissa Comstock, Geoffrey R. Hill, Stanley R. Riddell, Damian J. Green

This study shows that increasing BCMA density with GSI improves CAR T cell cytotoxicity but also enhances trogocytosis, leading to CAR T cell dysfunction and exhaustion.

bioRxiv · Jul 16, 2026 · PreprintCancer Biology