Stanley R. Riddell

Enhanced BCMA Antigen Density Increases Trogocytosis and Attenuates CAR T cell Function

This study shows that increasing BCMA density with GSI improves CAR T cell cytotoxicity but also enhances trogocytosis, leading to CAR T cell dysfunction and exhaustion.

Coordinated expansion of CD163⁺ monocytes and immature CD177⁺ neutrophils marks severe neurotoxicity after CD19 CAR T cell therapy

The paper identifies CD163+ monocytes and immature CD177+ neutrophils as markers of severe neurotoxicity after CD19 CAR T cell therapy through multi-omics profiling.

Myeloma and therapy reshape the bone marrow niche to durably constrain immune reconstitution and vaccine responsiveness

This study shows how multiple myeloma and its treatment alter the bone marrow niche, impairing immune reconstitution and vaccine responses, with mRNA vaccines showing better efficacy than influenza vaccines.

Quantifying HLA transcripts by genotype in chimeric mixtures at single-cell resolution

This paper introduces scrHLA-typing, a method to quantify HLA transcripts in single cells using long-read sequencing, showing its ability to detect allele-specific expression in post-transplant relapse samples.

Precise engineering of chimeric antigen receptor expression levels defines T cell identity and function

This study shows that varying CAR expression levels in T cells affects their activation, function, and transcriptional identity, with optimal CAR levels preventing exhaustion.