Multiple Myeloma associated DIS3 mutations drive AID-dependent IgH Translocations
Tomasz M. Kuliński, Olga Gewartowska, Mélanie Mahé, Karolina Kasztelan, Janina Durys, Anna Stroynowska-Czerwińska, Marta Jedynak-Slyvka, Ewelina P. Owczarek, Debadeep Chaudhury, Marcin Nowotny, Aleksandra Pękowska, Bertrand Séraphin, Andrzej Dziembowski
This study shows DIS3 mutations in multiple myeloma increase AID-dependent IgH translocations by altering chromatin interactions and RNA processing.
bioRxiv · Jul 27, 2023 · PreprintMolecular Biology