Marcin Nowotny

This study presents cryo-EM structures of UG10 enzymes and elucidates their enzymatic mechanism involving RT and primase domains, showing their anti-phage activity.

This paper presents the structures of herpesviral DNA-binding proteins ICP8 and BALF2 in DNA complexes, revealing mechanisms of DNA annealing and recombination.

The paper presents a cryo-EM structure of the human TRPM8 channel in the closed state and analyzes its ligand interactions and conformational states.

This study shows DIS3 mutations in multiple myeloma increase AID-dependent IgH translocations by altering chromatin interactions and RNA processing.

The paper investigates how the CHN-1/UFD-2 complex enhances ubiquitin chain formation through dimerization and chaperone-mediated regulation of substrate ubiquitylation.