Multiplexed in vivo base editing identifies functional gene-variant-context interactions
Jonuelle Acosta, Grace A. Johnson, Samuel I. Gould, Kexin Dong, Yovel Lendner, Diego Detrés, Ondine Atwa, Jari Bulkens, Samuel Gruber, Manuel E. Contreras, Alexandra N. Wuest, Varun K. Narendra, Michael T. Hemann, Francisco J. Sánchez Rivera
The paper uses in vivo base editing to systematically analyze the functional impact of genetic variants in cancer models, revealing context-dependent effects and limitations of CRISPR-Cas9.
bioRxiv · Feb 23, 2025 · PreprintCancer Biology