Author

Samuel Gruber

Koch Institute for Integrative Cancer Research At MIT

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alexandra N. WuestiD· 1 shared Diego Detrés· 1 shared Francisco J. Sánchez RiveraiD· 1 shared Grace A. Johnson· 1 shared Jari Bulkens· 1 shared Jonuelle AcostaiD· 1 shared Kexin DongiD· 1 shared Manuel E. Contreras· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alexandra N. WuestORCID

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1 paper

Recent·Most cited

Multiplexed in vivo base editing identifies functional gene-variant-context interactions

Jonuelle Acosta, Grace A. Johnson, Samuel I. Gould, Kexin Dong, Yovel Lendner, Diego Detrés, Ondine Atwa, Jari Bulkens, Samuel Gruber, Manuel E. Contreras, Alexandra N. Wuest, Varun K. Narendra, Michael T. Hemann, Francisco J. Sánchez Rivera

The paper uses in vivo base editing to systematically analyze the functional impact of genetic variants in cancer models, revealing context-dependent effects and limitations of CRISPR-Cas9.

bioRxiv · Feb 23, 2025 · PreprintCancer Biology