Author

Manuel E. Contreras

Koch Institute for Integrative Cancer Research At MIT

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandra N. WuestiD· 2 shared Francisco J. Sánchez RiveraiD· 2 shared Grace A. Johnson· 2 shared Jonuelle AcostaiD· 2 shared Michael T. HemanniD· 2 shared Samuel I. GouldiD· 2 shared Alinur Jaboldinov· 1 shared Angela N. KoehleriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCancer Biology

Alexandra N. WuestORCID

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2 papers

Recent·Most cited

A functional map of CDK-drug interactions at single amino acid resolution

Samuel I. Gould, Jonuelle Acosta, Luca Boscolo Bielo, Alinur Jaboldinov, Grace A. Johnson, Manuel E. Contreras, Alexandra N. Wuest, Emmanuel Brémont, Mohammed A. Toure, Yichen Xiang, Zuzanna Kozicka, Michael T. Hemann, Angela N. Koehler, Sarat Chandarlapaty, Francisco J. Sánchez Rivera

The paper maps CDK-drug interactions at single amino acid resolution using genome editing and computational analysis, identifying critical residues and resistance mechanisms.

bioRxiv · Nov 2, 2025 · PreprintCancer Biology

Multiplexed in vivo base editing identifies functional gene-variant-context interactions

Jonuelle Acosta, Grace A. Johnson, Samuel I. Gould, Kexin Dong, Yovel Lendner, Diego Detrés, Ondine Atwa, Jari Bulkens, Samuel Gruber, Manuel E. Contreras, Alexandra N. Wuest, Varun K. Narendra, Michael T. Hemann, Francisco J. Sánchez Rivera

The paper uses in vivo base editing to systematically analyze the functional impact of genetic variants in cancer models, revealing context-dependent effects and limitations of CRISPR-Cas9.

bioRxiv · Feb 23, 2025 · PreprintCancer Biology