Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein
Marie‐Lynn Cuypers, Tom Jaspers, Jarne Clerckx, Simon Leekens, Christopher Cawthorne, Guy M Bormans, Frederik Cleeren, Nick Geukens, Bart De Strooper, Maarten Dewilde
This paper demonstrates that binding antibodies to myelin oligodendrocyte glycoprotein (MOG) significantly increases their brain half-life when combined with transferrin receptor (TfR) mediated transport.
Fluids and Barriers of the CNS · Jan 30, 2025Peer-reviewedPharmacology & Toxicology