Author

Christopher Cawthorne

KU LeuvenORCID 0000-0002-5975-0354Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Organism:rat· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

Koen Van LaereiD· 2 shared Ana Catarina Carapinha CascalhoiD· 1 shared Bart De StrooperiD· 1 shared Bert Malengier-Devlies· 1 shared Birgit WeynandiD· 1 shared Carolien De Keyzer· 1 shared Chris Van den HauteiD· 1 shared Diego CabezudoiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Koen Van LaereORCID

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3 papers

Recent·Most cited

Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits

María Sanchiz-Calvo, Elena Coccia, Christopher Cawthorne, Gustavo Morrone Parfitt, Teresa Torre-Muruzabal, George Tsafaras, Koen Van Laere, Diego Cabezudo, Ana Catarina Carapinha Cascalho, Chris Van den Haute, Peter Vangheluwe, Joel Blanchard, Eduard Bentea, Veerle Baekelandt

This study shows that ATP10B loss causes dopaminergic neuron death and Parkinsonian symptoms in rats and human stem cell models.

Acta Neuropathologica · Jul 17, 2025Peer-reviewedNeuroscience

Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein

Marie‐Lynn Cuypers, Tom Jaspers, Jarne Clerckx, Simon Leekens, Christopher Cawthorne, Guy M Bormans, Frederik Cleeren, Nick Geukens, Bart De Strooper, Maarten Dewilde

This paper demonstrates that binding antibodies to myelin oligodendrocyte glycoprotein (MOG) significantly increases their brain half-life when combined with transferrin receptor (TfR) mediated transport.

Fluids and Barriers of the CNS · Jan 30, 2025Peer-reviewedPharmacology & Toxicology

A single-dose live-attenuated YF17D-vectored SARS-CoV2 vaccine candidate

Lorena Sanchez Felipe, Thomas Vercruysse, Sapna Sharma, Ji Ma, Viktor Lemmens, Dominique van Looveren, Mahadesh Prasad Arkalagud Javarappa, Robbert Boudewijns, Bert Malengier-Devlies, Suzanne F. Kaptein, Laurens Liesenborghs, Carolien De Keyzer, Lindsey Bervoets, Madina Rasulova, Laura Seldeslachts, , Kai D

This paper develops a single-dose YF17D-vectored SARS-CoV-2 vaccine candidate that induces neutralizing antibodies and protects against infection in hamsters.

bioRxiv · Jul 8, 2020 · PreprintMicrobiology