Tom Jaspers

A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies

This paper develops a pair of congenic mice for PET/CT imaging of transplants using anti-TfR nanobodies, showing their ability to track transplanted cells without genetic modification.

Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein

This paper demonstrates that binding antibodies to myelin oligodendrocyte glycoprotein (MOG) significantly increases their brain half-life when combined with transferrin receptor (TfR) mediated transport.

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's Disease

The paper shows that astrocyte calcium dysfunction leads to early network hyperactivity in Alzheimer's Disease, which can be reversed by restoring calcium signaling.