Pharmacology & ToxicologyFluids and Barriers of the CNSPeer-reviewed
Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein
Marie‐Lynn Cuypers, Tom Jaspers, Jarne Clerckx…·Maarten Dewilde
This paper demonstrates that binding antibodies to myelin oligodendrocyte glycoprotein (MOG) significantly increases their brain half-life when combined with transferrin receptor (TfR) mediated transport.
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